The Comfort Inn & Suites hotel offers a convenient Interstate location, walking distance from the VF Factory Outlet mall. It is minutes from points of interest like Bootheel Golf Club, the historic Sikeston Depot, Veteran's Park and Beggs Family...

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Sikeston is a city located both in southern Scott County and northern New Madrid County, in the state of Missouri, United States. See more information from the Comfort Inn & Suites Sikeston in the Sikeston, Missouri. It is situated just north of the "Missouri Bootheel", although many locals consider Sikeston a part of it. The cost of living in the Comfort Inn & Suites Sikeston located in the Sikeston, Missouri from 83$. By way of Interstate 55, Interstate 57, and U.S. Comfort Inn & Suites Sikeston in the Sikeston, Missouri on the detailed map. Route 60, Sikeston is close to the halfway point between St. The cost of living in the Comfort Inn & Suites Sikeston located in the Sikeston, Missouri from 83$. Louis and Memphis, Tennessee and is three hours from Nashville. We remind you that the Comfort Inn & Suites Sikeston is located in the Sikeston, Missouri. The city is named after John Sikes, who founded it in 1860. We remind you that the Comfort Inn & Suites Sikeston is located in the Sikeston, Missouri. It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143. As of the 2010 census, the city population was 16,318, making it the fourth-most populous city in Missouri's 8th Congressional district behind Cape Girardeau, Rolla, and Poplar Bluff and just ahead of Farmington. Comfort Inn & Suites Sikeston in the Sikeston, Missouri on the detailed map. Before the 2010 census, it had been the second-most populous city in the district.. Comfort Inn & Suites Sikeston in the Sikeston, Missouri on the detailed map.